SpliceInfo
    An information repository for mRNA alternative splicing in human genome
Home Search Documentations Download

SpliceInfo : Several modes of mRNA alternative splicing, such as exon skipping, alternative 5'-splicing sites, alternative 3'-splicing sites and mutually exclusive exons are computationally derived and extracted. Finally, for each type of alternative splicing, the flanking intronic sequences are collected and then exploited by motif discovery tools. The tissue-specific information and gene functionalities that correspond to the selected regions are also considered. The database provides a means of investigating alternative splicing and can be used for identifying alternative splicing - related motifs, such as the exonic splicing enhancer (ESE), the exonic splicing silencer (ESS) and other intronic splicing motifs.

Cititng SplieInfo
H.D. Huang, J.T. Horng, F.M. Lin, Y.C. Chang, and C.C. Huang. (2005) "SpliceInfo: An information repository for mRNA alternative splicing in human genome ", Nucleic Acids Research, Vol. 33, D80-D85. [PubMed]


Query By Gene
 

    Query Fields                

   (Gene Name, e.g., BRC)
   (Ensembl Gene ID, e.g., ENSG00000141837)
   (Swiss-Prot Protein Accession Number, e.g., O43497)
   (NCBI RefSeq Protein ID, e.g., NP_005239.1)
   (NCBI UniGene ID, e.g., Hs.122359)



Query By Filtering Constraints
 
Gene Lists Ensembl_Gene_ID Lists
Gene_Name Lists
Splicing Type
Containing Spliced-Out Protein Domain
Filtering Constraints Alternative Splicing Modes
Containing Repeat Feature (e.g., SINE, LINE,...)
GC Ratio of Exons >=
Minimum Exon/Intron Length >=
Tissue Specificity [EST evidences]  Choose a Tissue
Tissue Specificity [Protein evidences]  Choose a Tissue
Containing Protein Domains
Gene Ontology Aspect
Gene Ontology Term
     
   Demo 1  :   Name group of genes which has annotations of Exonic Splicing Enhancers (ESEs).
   Demo 2  :   Name group of genes which has annotations of Exonic Splicing Silencers (ESSs).
   Demo 3  :   Name group of genes which has annotations of Intronic Splicing Enhancers (ISEs) or Silencers (ISSs).
   Demo 4  :   Filtering constraints of BRCA exon skipping.

   Case Study 1  :   An alternative spliced gene (BRCA1)
   Case Study 2  :   A variety of genes which has ESEs
   Case Study 3  :   Conserved exon skipping between human and mouse

   GoTo SpliceMotif


Department of Computer Science and Information Engineering, National Central University, Taiwan
Department of Biological Science and Technology, Institute of Bioinformatics
National Chiao Tung University,Hsinchu, Taiwan
Contact with: bryan@mail.NCTU.edu.tw



Array
(
    [login] => 1
    [mysid] => jp4s9grjej99oc3fg60nj35j57
    [email] => hcc@db.csie.ncu.edu.tw
)